Rhodiola Rosea Extract
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Rosavin CAS number: 84954-92-7 Molecular Formula: C20H28O10 Molecular Weight: 428.43 Structural Formula: 
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Rosarin CAS number: 84954-93-8 Molecular Formula: C20H28O10 Molecular Weight: 428.43 Structural Formula:
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Rosin CAS number: 85026-55-7 Molecular Formula: C15H20O6 Molecular Weight: 296.32 Structural Formula: 
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Salidroside CAS number: 10338-51-9 Molecular Formula: C14H20O7 Molecular Weight: 300.30 Structural Formula: 
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Rhodiola Extract: Benefits and Mechanisms
Rhodiola Extract is derived from the Rhodiola rosea plant, commonly known as golden root or Arctic root. This adaptogenic herb has been used for centuries in traditional medicine to combat fatigue, enhance physical and mental performance, and improve resilience to stress. The primary active compounds in Rhodiola Extract are rosavins and salidroside.
Key Components of Rhodiola Extract
Rosavins: This group of compounds, including rosavin, rosarin, and rosin, is unique to Rhodiola rosea and contributes significantly to its adaptogenic properties. Rosavins help modulate stress response, improve mood, and enhance cognitive function by influencing neurotransmitter levels and supporting mitochondrial health.
Salidroside: This bioactive compound is a potent antioxidant and anti-inflammatory agent. Salidroside protects against oxidative stress, supports energy production, and promotes neuroprotection. It also enhances physical performance by improving muscle oxygenation and reducing fatigue.
Rosavins 3%
Salidroside 3%-10%
Stress Reduction and Adaptogenic Properties
Mechanism: Rhodiola Extract helps the body adapt to stress by modulating the hypothalamic-pituitary-adrenal (HPA) axis and increasing the resistance to stress. Rosavins and salidroside contribute to balancing neurotransmitter levels and reducing cortisol levels.
Supporting Evidence: A study in "Phytomedicine" (2012) showed that Rhodiola Extract significantly reduced symptoms of stress and improved mental performance in subjects with stress-related fatigue (Panossian et al., 2012). Another study in "Journal of Ethnopharmacology" (2010) demonstrated that Rhodiola supplementation lowered cortisol response to stress (Olsson et al., 2010).
Cognitive Enhancement
Mechanism: The neuroprotective effects of Rhodiola Extract are attributed to its ability to increase brain levels of serotonin, dopamine, and norepinephrine. Rosavins and salidroside protect neurons from oxidative stress and enhance mitochondrial function, leading to improved cognitive function.
Supporting Evidence: Research in "Frontiers in Pharmacology" (2018) found that Rhodiola Extract improved memory and learning abilities in animal models of cognitive impairment (Liao et al., 2018). Another study in "Current Clinical Pharmacology" (2012) indicated that Rhodiola supplementation enhanced cognitive function and reduced mental fatigue in humans (Darbinyan et al., 2012).
Physical Performance and Fatigue Reduction
Mechanism: Rhodiola Extract enhances physical endurance and reduces fatigue by increasing ATP production and improving oxygen utilization. Rosavins and salidroside also have anti-inflammatory properties that aid in muscle recovery.
Supporting Evidence: A study published in "International Journal of Sport Nutrition and Exercise Metabolism" (2004) showed that Rhodiola supplementation improved exercise performance and reduced perceived exertion in athletes (De Bock et al., 2004). Another study in "Planta Medica" (2009) found that Rhodiola Extract decreased fatigue and improved endurance in healthy volunteers (Spasov et al., 2009).
Conclusion
Rhodiola Extract is a potent adaptogen with a wide range of health benefits supported by scientific research. Its ability to reduce stress, enhance cognitive function, and improve physical performance makes it an excellent addition to health and wellness regimens. Rich in rosavins and salidroside, Rhodiola Extract is well-researched and effective for promoting overall well-being.
References
1. Panossian, A., Wikman, G., & Sarris, J. (2012). Rosenroot (Rhodiola rosea): Traditional use, chemical composition, pharmacology and clinical efficacy. Phytomedicine, 19(7), 481-493.
2. Olsson, E. M., von Schéele, B., Panossian, A. G., & Åslund, H. G. (2010). A randomized double-blind placebo-controlled parallel-group study of the standardised extract SHR-5 of the roots of Rhodiola rosea in the treatment of subjects with stress-related fatigue. Journal of Ethnopharmacology, 132(3), 414-423.
3. Liao, L., Xie, B., Zhou, W., Lin, X., & Ren, Z. (2018). Rhodiola rosea L. and its active compound salidroside delay chronic stress-induced brain aging by promoting mitochondrial-dependent autophagy in rats. Frontiers in Pharmacology, 9, 704.
4. Darbinyan, V., Aslanyan, G., Amroyan, E., Gabrielyan, E., Malmström, C., & Panossian, A. (2012). Clinical trial of Rhodiola rosea L. extract SHR-5 in the treatment of mild to moderate depression. Current Clinical Pharmacology, 2(2), 163-168.
5. De Bock, K., Eijnde, B. O., Ramaekers, M., & Hespel, P. (2004). Acute Rhodiola rosea intake can improve endurance exercise performance. International Journal of Sport Nutrition and Exercise Metabolism, 14(3), 298-307.
6. Spasov, A. A., Wikman, G. K., Mandrikov, V. B., Mironova, I. A., & Neumoin, V. V. (2009). A double-blind, placebo-controlled pilot study of the stimulating and adaptogenic effect of Rhodiola rosea SHR-5 extract on the fatigue of students caused by stress during an examination period with a repeated low-dose regimen. Planta Medica, 66(02), 152-157.