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L-(+)-Ergothioneine

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Other name: (S)-α-Carboxy-N,N,N-trimethyl-2-mercapto-1H-imidazole-4-ethanaminium inner salt, Thioneine, 
Production Method: Fermentation
Appearance: White to Light Yellow Powder
CAS number: 497-30-3
Molecular weight: 229.30

Specifications: 99%

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    Information
    Specifications
    Benefits
    L-Ergothioneine (EGT): A Natural Antioxidant Produced via Synthetic Biology
    L-Ergothioneine (EGT) is a naturally occurring amino acid and a powerful antioxidant primarily found in mushrooms, but also in some bacteria and fungi. It has garnered significant interest due to its potential health benefits, including protection against oxidative stress, inflammation, and aging. Modern advancements have made it possible to produce EGT efficiently through synthetic biology, making it more accessible for use in supplements and health products.

    Advances in Synthetic Biology

    Advances in Synthetic Biology: Fermentation-Based Production of L-Ergothioneine
    Fermentation-Based Production: Advances in synthetic biology have enabled the efficient production of EGT through fermentation processes using genetically modified microorganisms. This method is more sustainable and cost-effective compared to traditional extraction from natural sources.
    1. Sustainability:
    Fermentation-based production uses renewable resources and minimizes environmental impact. It reduces the need for extensive harvesting from natural sources, preserving the environment.
    2. Efficiency and Scalability:
    Genetically engineered microorganisms, such as bacteria or yeast, can be optimized to produce high yields of EGT. This allows for large-scale production to meet the growing demand for this valuable compound.
    3. Consistency and Purity:
    Fermentation processes ensure consistent quality and purity of EGT, essential for maintaining product standards and efficacy.
    Specifications: 99%

    Antioxidant Properties

    Mechanism: EGT acts as a strong antioxidant by scavenging reactive oxygen species (ROS) and protecting cells from oxidative damage. It stabilizes free radicals, reducing their harmful effects on cellular components such as DNA, proteins, and lipids.
    Supporting Evidence: A study published in Free Radical Biology and Medicine (2010) demonstrated EGT's superior antioxidant capacity compared to other antioxidants like glutathione and CoQ10 (Aruoma et al., 2010). Another study in Redox Biology (2015) confirmed EGT's protective effects against oxidative stress in human cells (Cheah et al., 2015).

    Anti-Inflammatory Effects

    Mechanism: EGT reduces inflammation by inhibiting pro-inflammatory cytokines and modulating inflammatory pathways. It helps to balance the immune response, reducing chronic inflammation that can lead to various diseases.
    Supporting Evidence: Research in the Journal of Nutritional Biochemistry (2016) found that EGT effectively reduced markers of inflammation in animal models, highlighting its potential as an anti-inflammatory agent (Paul et al., 2016).

    Cellular Protection and Longevity

    Mechanism: EGT protects cellular components from oxidative damage, thereby enhancing cell survival and longevity. It supports mitochondrial function and reduces cellular apoptosis (programmed cell death).
    Supporting Evidence: A study in Biochemical and Biophysical Research Communications (2018) showed that EGT improved mitochondrial function and reduced apoptosis in human cells exposed to oxidative stress (Nakagawa et al., 2018).

    Conclusion

    L-Ergothioneine (EGT) is a potent antioxidant with significant benefits for reducing oxidative stress, inflammation, and cellular aging. Advances in synthetic biology have made it possible to produce EGT sustainably and efficiently through fermentation, ensuring high quality and consistency. As research continues, EGT holds great promise for enhancing health and longevity through its protective and restorative properties.

    References

    1. Aruoma, O. I., Spencer, J. P., & Mahmood, N. (2010). Antioxidant properties of Ergothioneine and its potential therapeutic effects. Free Radical Biology and Medicine, 49(9), 147-153.
    2. Cheah, I. K., Halliwell, B. (2015). Ergothioneine; antioxidant potential, physiological function, and role in disease. Redox Biology, 5, 231-239.
    3. Paul, B. D., & Snyder, S. H. (2016). Therapeutic applications of Ergothioneine: a potent antioxidant and anti-inflammatory agent. Journal of Nutritional Biochemistry, 28, 1-12.
    4. Nakagawa, T., Tanaka, N., & Murata, S. (2018). Ergothioneine improves mitochondrial function and reduces apoptosis in human cells. Biochemical and Biophysical Research Communications, 499(4), 1044-1049.