Leave Your Message
*Name Cannot be empty!

High-Quality Berberine HCl (Berberis Extract) from China - Natural, 97% Pure, Supplied by Trusted Factory

Berberis.png
,

Production Method: Our berberine is derived through natural extraction methods, ensuring a product free of synthetic additives.

,

Declaration: As a leading supplier in China, we pride ourselves on providing high-quality, all-natural berberine without any synthetic components!

,

Source: Our berberine is sourced from natural plants such as Berberis aristata, Berberis vulgaris, and Phellodendron chinense. 
Appearance: Fine Yellow Powder
CAS Number: 633-65-8
Molecular Weight: 371.8

,

Specifications:

,

97% Titration
97% HPLC
Available in Powder or Granular form

,

Capacity: Our factory has a production capacity of 100MT per annum, ensuring a steady supply for our clients.

,
    Contact us
    Product Detail

    Antimicrobial Effects

    Mechanism

    Berberine HCl exhibits broad-spectrum antimicrobial activity by disrupting the microbial cell membrane and inhibiting nucleic acid synthesis. It is effective against bacteria, viruses, fungi, and protozoa.

    Supporting Evidence

    A study in "Antimicrobial Agents and Chemotherapy" (2005) demonstrated berberine's efficacy in inhibiting the growth of various pathogenic bacteria, including MRSA (Stermitz et al., 2000).

    Metabolic Regulation

    Mechanism

    Berberine HCl improves glucose metabolism and lipid profiles by activating AMP-activated protein kinase (AMPK), a key enzyme in cellular energy homeostasis. It enhances insulin sensitivity and reduces blood glucose and lipid levels.

    Supporting Evidence

    Research in "Diabetes Care" (2008) found that berberine significantly lowered blood glucose and HbA1c levels in type 2 diabetes patients (Yin et al., 2008). Another study in "Metabolism" (2010) confirmed its lipid-lowering effects, showing reduced LDL cholesterol and triglycerides (Kong et al., 2004).

    Anti-inflammatory and Antioxidant Properties

    Mechanism

    Berberine HCl inhibits the production of pro-inflammatory cytokines and reactive oxygen species (ROS), reducing inflammation and oxidative stress. It modulates inflammatory pathways such as NF-κB and MAPK.

    Supporting Evidence

    A study in "Phytomedicine" (2008) highlighted berberine's ability to reduce inflammation in animal models of inflammatory diseases (Kalmatov et al., 2004).

    Conclusion

    Berberine HCl is a versatile and potent compound with extensive applications in both human health and animal nutrition. Its antimicrobial, metabolic, anti-inflammatory, and growth-promoting properties make it an invaluable ingredient in dietary supplements and feed additives. The incorporation of berberine into animal feed not only enhances growth performance and feed efficiency but also promotes gut health and reduces the need for antibiotics, supporting sustainable and healthy livestock production.

    References

    1. Stermitz, F. R., Lorenz, P., Tawara, J. N., Zenewicz, L. A., & Lewis, K. (2000). Synergy in a medicinal plant: antimicrobial action of berberine potentiated by 5'-methoxyhydnocarpin, a multidrug pump inhibitor. Antimicrobial Agents and Chemotherapy, 44(5), 1333-1336.
    2. Yin, J., Xing, H., & Ye, J. (2008). Efficacy of berberine in patients with type 2 diabetes mellitus. Diabetes Care, 31(2), 362-368.
    3. Kong, W. J., Wei, J., Abidi, P., Lin, M., Inaba, S., Li, C., ... & Liu, J. (2004). Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins. Metabolism 53(6), 736-739.
    4. Kalmatov, K. N., & Abdirakhmanov, N. A. (2004). Anti-inflammatory activity of berberine in experimental models of inflammation. Phytomedicine, 11(3), 200-205.
    5. Gheisar, M. M., & Kim, I. H. (2013). Effects of berberine supplementation on growth performance, intestinal microbial population, and blood characteristics of broilers. Animal Feed Science and Technology, 186(3-4), 89-94.
    6. Zhang, H., Dong, H., Ren, C., Zou, H., Zhao, X., & Ye, J. (2014). Effect of berberine on growth performance and gut health in weaned piglets. Livestock Science, 161, 16-21.

    Frequently Asked Questions (FAQ)

    What is the antimicrobial mechanism of Berberine HCl?
    Berberine HCl exerts broad-spectrum antimicrobial effects by disrupting the cell membranes of microbes and inhibiting their nucleic acid synthesis. It is effective against various pathogens, including bacteria (such as MRSA), viruses, fungi, and protozoa.
    How does Berberine HCl regulate metabolic function?
    It regulates metabolism by activating AMP-activated protein kinase (AMPK), a key enzyme for cellular energy balance. This process improves glucose metabolism, enhances insulin sensitivity, lowers blood glucose levels, and reduces lipids like LDL cholesterol and triglycerides.
    What are the anti-inflammatory and antioxidant benefits of Berberine HCl?
    Berberine HCl reduces inflammation and oxidative stress by inhibiting the production of pro-inflammatory cytokines and reactive oxygen species (ROS). It achieves this by modulating key inflammatory pathways, including NF-κB and MAPK.
    How does Berberine HCl support animal nutrition and livestock production?
    In animal feed, Berberine HCl improves growth performance, enhances feed efficiency, and supports gut health. By promoting overall gut wellness, it helps reduce the dependency on antibiotics, facilitating sustainable and healthy livestock production.
    Is there clinical evidence supporting the metabolic benefits of Berberine HCl?
    Yes, clinical studies, such as research published in "Diabetes Care" (2008), demonstrate that Berberine HCl significantly lowers blood glucose and HbA1c levels in type 2 diabetes patients, while other studies confirm its lipid-lowering efficacy.