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Fisetin Extract 50%-98% HPLC - Premium Yellow Powder from China Suppliers | Trusted Factory

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Product Overview: Our premium herbal extract, derived from Cotinus Coggygria Scop, is renowned for its quality and efficacy. This yellow powder is available with a concentration of 50%-98% (HPLC) and is produced using a meticulous extraction method to ensure the highest purity.

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Key Information:
CAS Number: 528-48-3
Molecular Weight: 286.24
Annual Capacity: 50MT/A

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As a leading supplier in China, we take pride in our state-of-the-art factory that adheres to stringent quality control measures. Our commitment to excellence makes us a reliable partner for all your herbal extract needs.

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    Product Detail

    Antioxidant and Anti-inflammatory Effects

    Mechanism

    Fisetin exerts strong antioxidant activity by scavenging free radicals and enhancing the activity of endogenous antioxidant enzymes. It also reduces inflammation by inhibiting the production of pro-inflammatory cytokines and downregulating inflammatory pathways such as NF-κB.

    Supporting Evidence

    A study in Molecules (2019) highlighted fisetin's ability to reduce oxidative stress and inflammation in various cell and animal models, suggesting its potential to protect against chronic diseases (Khan et al., 2019).

    Neuroprotection

    Mechanism

    Fisetin supports brain health by promoting neurogenesis, reducing neuroinflammation, and preventing neuronal damage. It enhances memory and cognitive function by modulating signaling pathways involved in synaptic plasticity.

    Supporting Evidence

    Research in Frontiers in Aging Neuroscience (2016) demonstrated that fisetin improved cognitive function and reduced neuroinflammation in animal models of Alzheimer's disease, indicating its potential as a neuroprotective agent (Currais et al., 2016).

    Senolytic Activity

    Mechanism

    Fisetin induces apoptosis in senescent cells, which are cells that have stopped dividing and contribute to aging and age-related diseases. By clearing these dysfunctional cells, fisetin helps improve tissue function and reduce inflammation.

    Supporting Evidence

    A study published in EBioMedicine (2018) showed that fisetin selectively eliminated senescent cells and improved health span and lifespan in mice, suggesting its role in promoting healthy aging (Yousefzadeh et al., 2018).

    Conclusion

    Fisetin is a versatile and potent flavonoid with extensive health benefits, including antioxidant, anti-inflammatory, neuroprotective, and senolytic properties. Its ability to modulate multiple biological pathways makes it a promising candidate for promoting health and longevity. Ongoing research continues to uncover its potential applications in preventing and treating various age-related conditions.

    References
    1. Khan, N., Afaq, F., & Mukhtar, H. (2019). Fisetin: A dietary antioxidant for health promotion. Molecules, 24(6), 1004.
    2. Currais, A., Prior, M., Dargusch, R., Armando, A., Ehren, J., Schubert, D., & Maher, P. (2016). Modulation of p25 and inflammatory pathways by fisetin maintains cognitive function in Alzheimer's disease transgenic mice. Frontiers in Aging Neuroscience, 8, 96.
    3. Yousefzadeh, M. J., Zhu, Y., McGowan, S. J., Angelini, L., Fuhrmann-Stroissnigg, H., Xu, M., ... & Robbins, P. D. (2018). Fisetin is a senotherapeutic that extends health and lifespan. EBioMedicine, 36, 18-28.

    Frequently Asked Questions

    What are the primary health benefits of Fisetin?
    Fisetin is a versatile and potent flavonoid that offers extensive health benefits, including strong antioxidant, anti-inflammatory, neuroprotective, and senolytic properties that support overall health and longevity.
    How does Fisetin exert its antioxidant and anti-inflammatory effects?
    Fisetin scavenges free radicals and enhances endogenous antioxidant enzymes. It also reduces inflammation by inhibiting the production of pro-inflammatory cytokines and downregulating key inflammatory pathways such as NF-κB.
    How does Fisetin support brain health and neuroprotection?
    Fisetin promotes neurogenesis, reduces neuroinflammation, and protects against neuronal damage. It has been shown to enhance memory and cognitive function by modulating signaling pathways related to synaptic plasticity.
    What is the senolytic activity of Fisetin?
    Fisetin acts as a senolytic agent by selectively inducing apoptosis (programmed cell death) in senescent cells. These are aging cells that have stopped dividing and contribute to tissue dysfunction and chronic inflammation.
    Is there scientific evidence supporting Fisetin's anti-aging potential?
    Yes. A 2018 study published in EBioMedicine demonstrated that Fisetin successfully eliminated senescent cells and extended both the health span and lifespan in animal models, supporting its potential role in healthy human aging.