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Fisetin Extract 50%-98% from China Suppliers | Quality Yellow Powder | Factory Direct Supply

Fisetin.jpg
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Production Method: Extraction    
Source: Cotinus Coggygria Scop 
Appearance: Yellow Powder
CAS Number: 528-48-3
Molecular Weight: 286.24

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Specifications: 50%-98% (HPLC)
Capacity: 50MT/A

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Introducing high-quality Cotinus Coggygria extract sourced directly from reputable suppliers and manufactured in our state-of-the-art factory in China. Our product is meticulously processed using advanced extraction methods to ensure a pure yellow powder with a guaranteed potency of 50% to 98%, as verified by HPLC analysis. With a robust production capacity of 50MT/A, we are equipped to meet your bulk supply needs effectively. Choose our premium extract for reliable performance and quality.

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    Product Detail

    Antioxidant and Anti-inflammatory Effects

    Mechanism:

    Fisetin exerts strong antioxidant activity by scavenging free radicals and enhancing the activity of endogenous antioxidant enzymes. It also reduces inflammation by inhibiting the production of pro-inflammatory cytokines and downregulating inflammatory pathways such as NF-κB.

    Supporting Evidence:

    A study in Molecules (2019) highlighted fisetin's ability to reduce oxidative stress and inflammation in various cell and animal models, suggesting its potential to protect against chronic diseases (Khan et al., 2019).

    Neuroprotection

    Mechanism:

    Fisetin supports brain health by promoting neurogenesis, reducing neuroinflammation, and preventing neuronal damage. It enhances memory and cognitive function by modulating signaling pathways involved in synaptic plasticity.

    Supporting Evidence:

    Research in Frontiers in Aging Neuroscience (2016) demonstrated that fisetin improved cognitive function and reduced neuroinflammation in animal models of Alzheimer's disease, indicating its potential as a neuroprotective agent (Currais et al., 2016).

    Senolytic Activity

    Mechanism:

    Fisetin induces apoptosis in senescent cells, which are cells that have stopped dividing and contribute to aging and age-related diseases. By clearing these dysfunctional cells, fisetin helps improve tissue function and reduce inflammation.

    Supporting Evidence:

    A study published in EBioMedicine (2018) showed that fisetin selectively eliminated senescent cells and improved health span and lifespan in mice, suggesting its role in promoting healthy aging (Yousefzadeh et al., 2018).

    Conclusion

    Fisetin is a versatile and potent flavonoid with extensive health benefits, including antioxidant, anti-inflammatory, neuroprotective, and senolytic properties. Its ability to modulate multiple biological pathways makes it a promising candidate for promoting health and longevity. Ongoing research continues to uncover its potential applications in preventing and treating various age-related conditions.

    References

    1. Khan, N., Afaq, F., & Mukhtar, H. (2019). Fisetin: A dietary antioxidant for health promotion. Molecules, 24(6), 1004.
    2. Currais, A., Prior, M., Dargusch, R., Armando, A., Ehren, J., Schubert, D., & Maher, P. (2016). Modulation of p25 and inflammatory pathways by fisetin maintains cognitive function in Alzheimer's disease transgenic mice. Frontiers in Aging Neuroscience, 8, 96.
    3. Yousefzadeh, M. J., Zhu, Y., McGowan, S. J., Angelini, L., Fuhrmann-Stroissnigg, H., Xu, M., ... & Robbins, P. D. (2018). Fisetin is a senotherapeutic that extends health and lifespan. EBioMedicine, 36, 18-28.

    Frequently Asked Questions

    What are the primary health benefits of Fisetin?

    Fisetin is a potent flavonoid that offers key health benefits, including strong antioxidant, anti-inflammatory, neuroprotective, and senolytic properties that support overall health and longevity.

    How does Fisetin fight oxidative stress and inflammation?

    Fisetin neutralizes free radicals, boosts the body's natural antioxidant enzymes, and reduces inflammation by blocking pro-inflammatory cytokines and downregulating pathways like NF-κB.

    In what ways does Fisetin support brain health?

    It promotes neurogenesis, reduces neuroinflammation, prevents damage to brain cells, and helps enhance memory and cognitive functions by modulating synaptic plasticity pathways.

    What is Fisetin's senolytic activity?

    Fisetin targets and eliminates senescent cells (dysfunctional cells that have stopped dividing and promote aging). By clearing these cells, it helps restore tissue function and reduce systemic inflammation.

    Is there scientific evidence supporting Fisetin's longevity benefits?

    Yes, peer-reviewed research, including a notable 2018 study in EBioMedicine, demonstrates that fisetin selectively clears senescent cells and can extend both health span and lifespan in animal models.