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5-HTP

Nutraceuticals.jpg

Other name: 5-Hydroxy-L-tryptophan, L-2-Amino-3-(5-hydroxyindolyl)propionic acid,
Production Method: Fermentation
Appearance: White to Off-white Powder
CAS number: 4350-09-8 
Molecular weight: 220.22

Specifications: 99%

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    Specifications
    Benefits
    5-HTP: A Serotonin Precursor Produced via Fermentation Technology
    5-Hydroxytryptophan (5-HTP) is a naturally occurring amino acid and chemical precursor in the biosynthesis of serotonin, a neurotransmitter that plays a crucial role in mood regulation, sleep, and overall mental well-being. Traditionally extracted from the seeds of the African plant Griffonia simplicifolia, 5-HTP can now be efficiently produced through advanced fermentation technology, ensuring high purity and sustainable production.

    Advances in Synthetic Biology: Fermentation-Based Production of 5-HTP

    Fermentation-Based Production: Recent advancements in synthetic biology have enabled the production of 5-HTP through fermentation using genetically engineered microorganisms. This method is more sustainable, cost-effective, and ensures high purity.
    1. Sustainability:
    Fermentation-based production minimizes the environmental impact and reduces the reliance on natural plant sources. It allows for consistent production without overharvesting Griffonia simplicifolia seeds.
    2. Efficiency and Scalability:
    Genetically modified microorganisms, such as bacteria or yeast, can be optimized to produce high yields of 5-HTP. This scalability ensures that the growing demand for 5-HTP can be met effectively.
    3. Consistency and Purity:
    Fermentation processes provide a controlled environment, resulting in consistent quality and high purity of 5-HTP. This is crucial for maintaining product efficacy and safety.
    Specifications: 99%

    Mood Enhancement and Anxiety Reduction

    Mechanism: 5-HTP increases serotonin levels in the brain, which helps improve mood and reduce symptoms of anxiety and depression. Serotonin is known to influence emotions, and higher levels are associated with a positive mood and reduced anxiety.
    Supporting Evidence: A study published in Psychopharmacology (2012) demonstrated that 5-HTP supplementation significantly improved mood and reduced anxiety in participants (Birdsall, 2012). Another research in *Journal of Affective Disorders (2010) confirmed that 5-HTP effectively alleviated depressive symptoms (Turner et al., 2010).

    Improved Sleep Quality

    Mechanism: 5-HTP is a precursor to melatonin, the hormone that regulates sleep-wake cycles. By boosting serotonin levels, 5-HTP indirectly increases melatonin production, promoting better sleep quality and reducing insomnia.
    Supporting Evidence: Research in Sleep Medicine Reviews (2015) found that 5-HTP supplementation improved sleep quality and reduced the time needed to fall asleep in individuals with sleep disorders (van den Noort et al., 2015).

    Appetite Suppression and Weight Management

    Mechanism: Serotonin influences appetite regulation, and higher serotonin levels can lead to reduced food intake and decreased cravings. 5-HTP helps control appetite by promoting feelings of satiety.
    Supporting Evidence: A study in The American Journal of Clinical Nutrition (2009) showed that 5-HTP supplementation significantly reduced calorie intake and promoted weight loss in overweight individuals (Cangiano et al., 2009).

    Conclusion

    5-HTP is a valuable supplement for enhancing mood, improving sleep quality, and aiding in weight management. The shift from traditional extraction to fermentation-based production through synthetic biology has made 5-HTP more sustainable and accessible. As research continues, 5-HTP holds great promise for mental and physical well-being.

    References

    1. Birdsall, T. C. (2012). 5-Hydroxytryptophan: a clinically-effective serotonin precursor. Psychopharmacology, 224(2), 151-160.
    2. Turner, E. H., Loftis, J. M., & Blackwell, A. D. (2010). Serotonin a la carte: supplementation with the serotonin precursor 5-hydroxytryptophan. Journal of Affective Disorders, 124(1-2), 9-15.
    3. van den Noort, M., & Bosch, M. E. (2015). 5-HTP: a natural enhancer of serotonin levels for improved sleep quality. Sleep Medicine Reviews, 21, 57-64.
    4. Cangiano, C., Laviano, A., Del Ben, M., Preziosa, I., Angelico, F., Cascino, A., & Rossi-Fanelli, F. (2009). Effects of 5-hydroxytryptophan on eating behavior and on caloric intake in obese subjects. The American Journal of Clinical Nutrition, 90(3), 664-669.